The probable existence of a coenzyme form of biotin.
نویسنده
چکیده
It has been demonstrated that biotin is concerned with the enzymatic decarboxylation of oxalacetate (l-4), the reversible deamination of aspartate (5, S), and the deamination of serine and threonine (5,6). By analogy with other vitamins it might be suspected that biotin does not function in these reactions as such, but is converted into a coenzyme form. The evidence outlined below suggests that a coenzyme form of biotin does exist in certain natural materials.
منابع مشابه
The Probable Existence of a Coenzyme Form of Biotin
It has been demonstrated that biotin is concerned with the enzymatic decarboxylation of oxalacetate (l-4), the reversible deamination of aspartate (5, S), and the deamination of serine and threonine (5,6). By analogy with other vitamins it might be suspected that biotin does not function in these reactions as such, but is converted into a coenzyme form. The evidence outlined below suggests that...
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Since the advent of a novel technique of enzyme resolution of bacterial aspartic acid deaminase (Lichstein and Umbreit, 1947), this enzyme has been linked with biotin (Liclstein and Umbreit, 1947; Wright et al., 1949), with adenylic acid (Lichstein and Christman, 1948), and with a coenzyme present in yeast and liver extracts (Lichstein and Christman, 1949; Christman and Lichstein, 1950). These ...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 177 1 شماره
صفحات -
تاریخ انتشار 1949